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Tuesday 01 June 2004

Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages.

By: Ewart GD, Nasr N, Naif H, Cox GB, Cunningham AL, Gage PW.

Antimicrob Agents Chemother 2004 Jun;48(6):2325-30

We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.

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